New Research Project Launched!

BRCA1 and BRCA2 Missense Variants and Their Association with Ovarian Cancer Risk Across Ethnic Populations

The primary goal of this project is to investigate the impact of missense variants in BRCA1 and BRCA2 genes on ovarian cancer risk across diverse ethnic populations. While BRCA1 and BRCA2 mutations are well-documented risk factors for hereditary breast and ovarian cancer, the functional significance of missense variants remains poorly understood, particularly in underrepresented populations.

By integrating bioinformatics, genomic data analysis, and AI-driven variant interpretation, this study aims to:

• Identify high-risk BRCA1/2 missense variants that contribute to ovarian cancer susceptibility.

• Analyze ethnic-specific genetic variations to uncover disparities in cancer risk assessment.

• Enhance precision medicine approaches by improving genetic screening and risk prediction models.

This research is essential for reducing healthcare disparities and developing tailored genetic counseling strategies, ultimately contributing to more accurate cancer risk prediction and personalized treatment plans for diverse populations.